The 30-year-old defender played 94 minutes before being replaced by Karim Rekik, as Mendilibar's side claimed yet another famous European triumph - Sevilla's seventh in history.
Paulo Dybala had opened the scoring for Roma - currently managed by former United boss Jose Mourinho - inside the first half, before Gianluca Mancini put the ball in his own net ten minutes into the second period, forcing extra time.
With neither team able to find a way through during the additional 30 minutes, the tie was settled on penalties. Gonzalo Montiel, Argentina team-mate of United's Lisandro Martinez, scored the decisive spot-kick to hand Sevilla the trophy.