The Brazil midfielder's booking in the 4-4 draw with Bournemouth on Monday night means he must serve a one-game suspension.
United are also without the services of Noussair Mazraoui, Amad and Bryan Mbeumo, who are away in Morocco for the Africa Cup of Nations.
Speaking at his press conference to preview the 16:30 GMT kick-off at Villa Park, the head coach also ruled Matthijs de Ligt and Harry Maguire out of the clash.
The central defensive pair are continuing their recovery from injury at Carrington.
"I think everyone is well," he said. "We have one more training [session] but, today, the rest of the lads are ready to go.