The Reds make a swift return to the Amex Stadium, scene of Saturday's dramatic 3-2 victory in the Premier League, for the 19:45 BST kick-off, which presents an opportunity to progress to the quarter-finals of the competition.
After shuffling his pack for the win at Luton Town in the previous round, Ole has told us he is likely to adopt a similar approach for the match on the south coast, with the visit of Tottenham Hotspur to Old Trafford at the weekend looming large.
When asked if both teams will field very different line-ups to Saturday, the boss told MUTV's Stewart Gardner: “I’m not sure.