Ole Gunnar Solskjaer has confirmed Phil Jones, Luke Shaw and Axel Tuanzebe were not part of the group that travelled to Germany for the tie at Stadion Koln, but young midfielders James Garner and Ethan Galbraith were among those spotted boarding the plane in Manchester.
So the boss has some key decisions to make - first and foremost, who starts in goal.
Sergio Romero has started most of the matches in this competition but no call has been made on whether he keeps his place from the win over LASK, or if David De Gea returns between the posts.