The game starts at 02:30 BST (on Thursday morning) and is live on MUTV for subscribers not based in the US.
Both sides won their opening matches, with the Reds seeing off West Ham United 2-1, thanks to a Bruno Fernandes double, and the Cherries beating Everton 3-0.
Hence, the clash is crucial in helping to decide which club will lift the trophy at the weekend.
Head coach Ruben Amorim told MUTV that Bryan Mbeumo is unlikely to be rushed into action, indicating the recent buy from Brentford will not feature until Sunday's contest with Everton.