Both forwards had an impact off the bench in Wednesday’s 2-0 win at Newcastle, with Lukaku netting with his first touch to open the scoring, before Alexis set up Marcus Rashford’s goal.
Eric Bailly will sit out a second game through suspension and Solskjaer has also said that fellow defenders Chris Smalling and Marcos Rojo are again sidelined.
The caretaker manager also told reporters in his pre-match press conference that Paul Pogba is a doubt after sustaining a knock, presumably after a rash challenge by Jonjo Shelvey, but he is hopeful Marouane Fellaini will come through Friday's session at the Aon Training Complex.