Erik ten Hag's side bounced back following a defeat to Unai Emery's men on Sunday afternoon, which ended our nine-game unbeaten run.
Goals from Anthony Martial, Marcus Rashford, Bruno Fernandes and Scott McTominay helped the Reds get the better of the visitors this time around in an enthralling second half of the cup tie.
Following this evening's triumph, here are the talking points from Old Trafford...
RASHFORD'S ELECTRIC
Hours after being named in Gareth Southgate's England squad for the upcoming World Cup finals, Rashford reminded everybody exactly why he is there with an electric performance.