Our leading scorer missed both games against Aston Villa, the 1-0 victory in the FA Cup third round at Old Trafford and the 2-2 draw in the Midlands on Saturday.
The absence is because of a hip problem but both the Portugal international and Marcus Rashford, who suffered a dead leg in training, could be welcomed back into the fold for the journey to the capital.
"It [Ronaldo's absence] was because he was injured," Rangnick stated at his post-match press conference. "He still has problems with his [hip] flexor, that's why he couldn't train yesterday. We spoke before and after the training session and decided it makes no sense just to travel, without knowing if he can really play.