The Reds have the opportunity to bounce back from disappointing league defeats to Liverpool and Burnley by securing a place in the fifth round of the world-famous knockout competition.
Our hosts from League One secured a lucrative tie by overcoming a much-changed Watford team 2-1 after extra-time on Thursday night.
Victor Lindelof was ill and missed the 2-0 home loss to the Clarets on Wednesday, joining Marcos Rojo, Axel Tuanzebe, Scott McTominay, Paul Pogba and top scorer Marcus Rashford on the sidelines.
However, the Swede is set to return in the middle of the defence at Prenton Park.