The home match against the Seagulls is the final one before an international break and affords the Reds an opportunity to build on Thursday's Europa League triumph over Partizan Belgrade.
Scott McTominay and Harry Maguire appeared to sustain knocks in the 3-0 victory, with the Scotland international's ankle problem initially deemed the more serious.
Victor Lindelof missed the Partizan game due to an issue with his back but he could be in a position to return, even if the other sidelined players, such as Luke Shaw and Axel Tuanzebe, appear unlikely to figure. Paul Pogba has already been ruled out for the rest of the month, while Tim Fosu-Mensah and Eric Bailly are making progress after surgery.