The 26-year-old suffered an injury during the weekend's Emirates FA Cup third-round tie against Wolverhampton Wanderers at Molineux.
As a result, Maguire then missed Tuesday night's Carabao Cup semi-final first leg against Manchester City, when Phil Jones started in his place.
Speaking after the match, Ole Gunnar Solskajer was unable to provide a positive medical report on his defender and occasional captain.
Asked how long Maguire might be out for, having missed the tie with City, the boss said: “We don’t know. It is not going to be a long term one.
“But I don’t think he will be ready for the weekend.