The Reds won their last league match at Old Trafford against Watford with Anthony Martial scoring. The Frenchman is back in the starting XI to face the Hammers after being a sub in the last two matches against Wolves and Barca.
The manager has had to shuffle his back four with both Luke Shaw and Ashley Young suspended for the game.
Shaw’s accumulation of yellow cards has brought him a ban and he is replaced at left back by Marcos Rojo with the Argentinian starting only his third Premier League match of the campaign.
Young was sent off in the away league defeat at Wolves and his ban means Diogo Dalot is in the side for his third successive game.