The Swedish centre back withdrew from his country’s internationals during the break and wasn't selected by the Reds, ending a run of 12 consecutive matches for the side.
But newly appointed permanent manager Solskjaer said: “Victor is not injured but he’s had some issues. He had a tough week so Victor will come back soon.”
Solskjaer’s first starting XI since being getting the manager’s job on a three-year contract on Thursday contains four changes from the Reds' disappointing exit from the Emirates FA Cup at Wolves. David De Gea, Ashley Young, Phil Jones and Juan Mata didn’t play in the 2-1 quarter-final defeat at Molineux, but that quartet come in against Watford to replace Sergio Romero, Diogo Dalot, Lindelof and Jesse Lingard in the line-up to start against the Hornets.