In advance of the 17:30 GMT kick-off, Skinner sat down with club media to conduct his exclusive pre-match interview.
Marc waxed lyrical about the occasion that Old Trafford brings, and what he expects from our players in the big game at our iconic stadium.
He also urged Reds supporters to come out in their thousands to cheer on our women's side, discussed how his team is full of role models, and more.
Below, you can read everything he had to say...
So Marc, how are you doing, especially after the result at the weekend [in the FA Cup quarter-final against Lewes]?