Los Rojiblancos are currently tied at 2-2 with the Reds following the first-leg draw at Old Trafford last Thursday, with a late flourish from the visitors cancelling out Marcel Sabitzer's early brace.
Thursday's return leg will take place at the Ramon Sanchez Pizjuan stadium in Andalusia, with kick-off set for 20:00 BST.
Mendilibar has selected 21 men in his squad for the fixture, with one player that started in M16 missing from the list this time around.
21-man squad to face Manchester United ud83dudcaa
— Sevilla FC (@SevillaFC_ENG) April 19, 2023
Defender Gonzalo Montiel picked up an early booking at the Theatre of Dreams last week and will therefore miss Thursday's second leg through suspension.