The Reds made it to the last-four stage in three separate competitions last season, but failed to progress to the final on each occasion.
Should United defeat our cross-city neighbours at Old Trafford in this one-off tie, it would not only ensure a place in the Wembley cup final in April, but City’s monopoly over the competition would also be brought to an end.
Ahead of what is sure to be a dramatic night at the Theatre of Dreams, we have all the essential pre-match information…
HOW CAN I FOLLOW THE GAME?
The match kicks off at 19:45 GMT and will be broadcast live on Sky Sports in the UK.