Noussair Mazraoui has already missed the 4-4 draw with Bournemouth, after hosts Morocco insisted on his exit prior to Monday's Premier League game, with Amad (Ivory Coast) and Bryan Mbeumo (Cameroon) also now departing for the tournament.
While admitting his side will have to play a little differently, losing the rare ability Amad and Mbeumo have to dribble past their markers, the boss insists everybody is ready for the start of a busy festive period, away to an Aston Villa team that have won their last nine games, in all competitions.
In his exclusive pre-match chat with MUTV's Mark Sullivan at Carrington, Ruben also outlined what Benjamin Sesko brings to the frontline, with the Slovenia international making his comeback from a knee injury in the draw with Bournemouth, helping to set up Matheus Cunha's goal, our fourth of a crazy night at Old Trafford.