With one eye on next Thursday's UEFA Europa League semi-final second leg against Athletic Club at Old Trafford, Amorim has rested the majority of the team that performed brilliantly to secure a 3-0 lead from the first leg in Bilbao.
Only left wing-back Patrick Chinazaekpere Dorgu, midfielder Manuel Ugarte and forward Alejandro Garnacho retain their places in the XI, which features a first start for Chido Obi as the centre-forward.
The full team and substitutes are as follows:
Starting XI: Bayindir; Fredricson, De Ligt, Shaw (c); Chinazaekpere Dorgu, Ugarte, Mainoo, Amass; Garnacho, Mount; Obi.