Manchester United's no.7 tucked home Marcus Rashford's cross at the start of the second half to bring up the landmark figure.
He is clear of Ballon d'Or winner Lionel Messi in the overall list and continues to do the business at the highest level.
Indeed, he swiftly moved on to 801 with the penalty that took all three points from the 3-2 win over the Gunners.
CRISTIANO RONALDO'S 800th CAREER GOAL!
Witnessing greatness ud83dudc10#PLonPrime #MUNARS pic.twitter.com/ndInXAbTnc — Amazon Prime Video Sport (@primevideosport) December 2, 2021Some 115 of Ronaldo's strikes have come at international level for Portugal.