Strikes from Adrien Silva and Jakub Jankto secured a deserved victory for Claudio Ranieri’s side, meaning Roma are still seventh in the Italian top flight but cannot now mathematically make up the ground to AC Milan in fourth, with just four games to play.
The capital club currently occupy the league’s UEFA Conference League spot, although Sassuolo are now just two points behind after Roma’s recent indifferent run, which has seen them win just one of their last eight games.
Coach Paulo Fonseca made seven changes to the side which was beaten 6-2 at Old Trafford in last Thursday’s Europa League semi-final first leg, with four of them enforced.