Mary Earps, Maya Le Tissier, Ella Toone and Katie Zelem will all be heading to a sold-out King Power Stadium, in Leicester, on 27 October to face the Red Flames. Just four days later, they're set to travel to Belgium to face the same opposition in an away fixture to be held at Den Dreef.
The quartet will be joined on the trip by fellow Red Grace Clinton, who is currently on loan at Tottenham Hotspur. This represents the midfielder's first call-up to senior international action after stepping up from the England Women's Under-23s squad.
The Lionesses played two games in Group One of the Nations League last month, kicking off with a 2-1 victory over Scotland, before falling to a 2-1 defeat to the Netherlands days later.