Kick-off will be at 19:45 BST and the game will be broadcast live in the UK on Sky Sports.
The match has been brought forward by more than two weeks as a result of the London club’s victory over Crystal Palace in Sunday’s FA Cup semi-final at Wembley.
United had been due to face Chelsea on Sunday 15 May, but the Blues will now be contesting the FA Cup final against Liverpool on that weekend.
Confirmation of this fixture means we now have a full and confirmed schedule for the final few games of the season.