Our German tactician has never previously faced the black-suited Argentinian during his distinguished coaching career and is looking forward to the challenge in our last-16 ties.
Simeone is no stranger to English football fans, of course, following his role in David Beckham's infamous red card at the 1998 World Cup. The former midfielder also came up against United during the 1998/99 Treble-winning season, with Internazionale, during a top-class playing career.
Since hanging up his boots, Simeone has forged a reputation as one of the most accomplished managers in Europe after restoring the fortunes of Atletico in Spain.