The Reds will be looking to get back to winning ways in the top-flight, after Tuesday's 1-1 draw with Burnley sees us drop from fourth to sixth in the table.
Two of our main rivals for Champions League qualification, West Ham and Arsenal, battled to 1-0 victories during the week, although Tottenham were beaten 3-2 at home by Ralph Hasenhuttl's side.
The south-coast side are likely to provide stern opposition in M16 on Saturday too, but Rangnick could welcome Alex Telles back into the fold after his recent absence with COVID-19.
While the Brazilian's potential return is a boost given his strong recent form, the Reds will be missing Telles's compatriot Fred as he is still isolating with the virus.