Despite the Villans' current run, we're just seven points behind the third-placed side and will be hoping to close that gap at Villa Park.
It's a clash that provides plenty of intrigue, not least to those playing our United Predictions game ahead of the 16:30 GMT kick-off.
Stuck with your picks? Don't worry, we've enlisted some expert help in former Reds Wes Brown and Quinton Fortune – here's what they're going for...
WES BROWN
Five-time Premier League winner Wes Brown knows a thing or two about clinching three points in England's top tier.