A statement that was posted via their official Twitter account, @EquipeDeFrance on Monday afternoon revealed the 26-year-old has been replaced by Arsenal player Matteo Guendouzi due to an ankle problem.
Didier Deschamps's reigning World Cup-winners are preparing to face Albania and Andorra at the Stade de France on Saturday and next Tuesday.
Pogba had played a full match for United at the weekend, in the 1-1 draw against Southampton in the Premier League, and it currently remains unclear how serious his injury might be.
As ever, a full assessment will be made at the Aon Training Complex in due course.