Ole Gunnar Solskjaer and Pep Guardiola's teams have not met in front of a crowd since the Reds' memorable 2-0 win back in March 2020, so anticipation could not be much higher.
If you're one of the lucky fans that will be in attendance for Saturday's 12:30 GMT kick-off, our iconic match programme will be available to purchase all around Old Trafford.
But even if you can't be at the ground to see Ronaldo, Rashford and co, you can order this special edition of United Review direct to your front door and grab a memento from one of club football's greatest fixtures.