The Reds have never played in the competition before, since our reformation in 2018, and PSG's squad features two former United players who played a role in that journey to the pinnacle of women's club football for Marc Skinner's side - Jackie Groenen and Aissatou Tounkara.
Ahead of the highly-anticipated clash, read this extract from our digital matchday programme, which breaks down the French giants' squad that will face the Reds on the historic night.
Don't forget, you can purchase a physical copy of the programme from Leigh Sports Village at the match, for just £2.