The Reds have a healthy 6-2 advantage from the dramatic first leg at Old Trafford – can we finish the job when the teams reconvene at the Stadio Olimpico?
Here's all the essential information, ahead of a game that could see Ole Gunnar Solskjaer reach his first final as Manchester United manager...
HOW CAN I FOLLOW THE MATCH?
The match kicks off at 20:00 BST on Thursday and will be broadcast live in the UK via BT Sport. You can also follow the action via ManUtd.com and our Official App, where you’ll be able to check the live in-game data through our Match Centre.