With a spot in the semi-finals of Europe's elite club competition at stake, Ole Gunnar Solskjaer's squad will be under no illusions of the challenges that lie ahead if we want to book a ticket to the Wanda Metropolitano in Madrid at the beginning of June. All of the teams left in the competition have faced United before, either domestically or in European competition.
Here's how United have fared against our rivals for the trophy in the past...
IN THE DRAW
AJAX
Perhaps the standout result of the round of 16, after United's win over Paris Saint-Germain of course, was how the Dutch side sensationally saw off the reigning European champions, Real Madrid, at the Bernabeu after being 2-1 down going into the second leg.