The 18:00 BST kick-off comes hot on the heels of the superb 3-1 victory at Aston Villa, with a big home game against Liverpool just around the corner, on Thursday night.
Ole has made it clear he has been left with no option but to rotate his players for the arduous schedule.
Although several youngsters could be in the frame for an outing, there are a number of more experienced players who will be hoping for a start.
An update is awaited on the extent of Harry Maguire's ankle injury but it would appear likely that the skipper is to miss out on another reunion with his former club.