The Old Trafford game, which kicks off at 20:00 BST, is being shown exclusively live on MUTV, as a crowd of around 30,000 is set to cheer the Reds on against the newly promoted Bees.
After run-outs against Derby County and QPR, the chance to face Premier League opposition is another great opportunity for the boss to assess his options and get minutes in the tank for a number of his squad.
Donny van de Beek and Diogo Dalot are set to be on the bench after returning to training this week, but the game comes too soon for the likes of Dean Henderson and Bruno Fernandes.