The Dutch midfielder and the England international were brought on in the 87th minute for Bruno Fernandes and Scott McTominay as the Reds looked for a late equaliser in Bergamo.
Shortly after the duo's introduction, Cristiano Ronaldo smashed home a sensational volley to make it 2-2 and secure a vital point away from home in Europe.
After the match in Italy, manager Ole Gunnar Solskjaer was asked about the thinking behind bringing on van de Beek and Sancho for the latter stages of the match.
"I thought the qualities they have could make an impact," the Norwegian explained, before complimenting our talented no.