The Reds may have avoided the rigours of travelling into Europe, given Wednesday's game against Villarreal was at home, but being asked to play in the earliest Premier League match of this weekend, against Everton at 12:30 BST on Saturday, means Solskjaer's men have had only two days to recover and train since the midweek victory.
The manager has often spoken about the challenges presented by fixture schedules, highlighting situations where players have had little time to rest, both physically and mentally.
When asked about the situation in his pre-match press conference, Solskjaer told reporters the club had received "absolutely no explanation" for the tight turnaround, before adding, "well, it's TV.