The Sweden defender has been struggling with a muscular problem, picked up in the draw with Crystal Palace last month, and was due to be out until at least Christmas, but he returns today.
He is expected to be alongside Chris Smalling, who signed a new contract with the club on Saturday. Diogo Dalot and Matteo Darmian are likely to make up the rest of the backline.
Ander Herrera and Nemanja Matic will anchor the midfield for the Reds, with Marcus Rashford, Jesse Lingard and Ashley Young supporting Romelu Lukaku, the only survivor from Wednesday's starting XI against Valencia, in attack.