A bumper crowd is expected for the game, in which the Reds could extend our competition record and win an unprecedented 11th FA Youth Cup.
Members of the first team will be in attendance in M16 and several players from the senior dressing room have sent messages of support via social media before the match.
Marcus Rashford, who knows all about this tournament having first played in it as a 16-year-old, said: “Good luck tonight boys. I have great memories playing in the FA Youth Cup. We’re all fully behind you and I wanted to wish you all the best.