The Serbian is anticipating another good workout for the Reds, who will play in front of home fans for the first time since a limited crowd of 10,000 watched Edinson Cavani score a worldie in May's 1-1 draw with Fulham.
Another team from West London will provide the opposition in midweek and fans can still buy tickets to see the action in person.
"On Wednesday, we have another good match, against Brentford, so we have to keep working to see where we can improve," said Matic, after captaining United in Saturday's friendly defeat to Queens Park Rangers.