Spurs sit eighth in the Premier League table, four points behind the Reds, after an eventful season which saw the North Londoners change manager in mid-November.
Mourinho has helped lift Tottenham from 14th in the league into their current position, and the Portuguese will be keen to get one over on his old club and move a step closer to securing Champions League football in N17 for the fifth consecutive season.
Need a refresher on Spurs after football's break? We’ve got you covered…
TEAM NEWS
Like United, Tottenham have a number of star names back from injury after the three-month hiatus, with Harry Kane, Son Heung-Min, Steven Bergwijn and Moussa Sissoko – all of whom missed Spurs’ last game, in March – pictured in training yesterday (Tuesday).