Marc Skinner’s side seek a statement victory in the pursuit of UEFA Women’s Champions League qualification.
The Reds are currently in third spot, two points behind second-placed Arsenal and eight off Chelsea.
Here is the lowdown on the fixture, including how to watch and follow the events as they unfold...
HOW TO WATCH AND FOLLOW
The game kicks off on Wednesday at 20:15 BST at Leigh Sports Village. It will be shown live on Sky Sports Main Event, while you can listen to live radio commentary on the United App.
Liam Bradford and Siobhan Chamberlain are on duty, providing you with the best coverage of every kick.