The meeting pits together two of the Premier League’s current top six and the winner will book a spot in the last eight of the competition.
The Reds beat Watford and Liverpool to make it to this stage, while the Irons have eliminated Stockport County and Doncaster Rovers en route to the fifth round.
Ahead of the clash, here’s all the key pre-match information…
HOW CAN I FOLLOW THE MATCH?
The match at Old Trafford kicks off at 19:30 GMT on Tuesday evening and will be broadcast live in the UK on BBC One.