After a three-month hiatus, the European competitions return with United facing the Catalans for the 14th time in our history, although this is the first meeting between the clubs in this tournament.
Here's what you need to know before the action gets under way...
HOW CAN YOU FOLLOW THE GAME?
Our clash with Barcelona will be shown live on BT Sport and kick-off at the Nou Camp is scheduled for 17:45 GMT on Thursday.
MUTV will also provide exclusive build-up and post-match reaction, along with further must-see content being available on ManUtd.com and in the United App.