The Reds fell behind at Old Trafford via an early strike from Magpies midfielder Sean Longstaff, but parity was thankfully restored in speedy fashion thanks to a low finish from Martial on 24 minutes.
After Mason Greenwood and Marcus Rashford both scored to make it 3-1, Anthony sealed his first-ever brace at the Theatre of Dreams with a delicate chip over the goalkeeper on 51 minutes.
The former AS Monaco forward was substituted shortly after the hour mark, preventing him scoring a hat-trick, as Ole Gunnar Solskjaer rested him with Saturday’s trip to Burnley clearly in mind.