Alexis Sanchez could be out of action for up to eight weeks after the Manchester United forward picked up a knee injury in Saturday's 3-2 win over Southampton.
Sanchez started the match but was forced off after 52 minutes after colliding with Jan Bednarek.
Chile's national team physio told El Mercurio (h/t MailOnline's Jack Gaughan):
"We spoke to the player, and he had scans on the injury (on Sunday).
"He will be available for the Copa America, but he will be unavailable to play for between six and eight weeks.