Jose Mourinho has dropped Manchester United captain Wayne Rooney to the bench for the visit of rivals Arsenal.
The Old Trafford clash is the early kick-off in the Premier League and it promises to be an exciting match.
Arsene Wenger - whose Gunners have not won at Man United in the league since 2006 - renews his rivalry with Jose Mourinho as both sides look to keep within distance of their title rivals.
Star forward Zlatan Ibrahimovic is suspended, so Anthony Martial starts in his place, while England international Marcus Rashford is also in the XI.