It's the biggest game in the Spanish club's history and potentially the tie of the quarter-finals.
Granada's meeting with Manchester United pitches European debutants with Champions League perennials.
So, who are the underdogs trying to cause the shock of the round against Ole Gunnar Solskjaer's team? Sportsmail takes a closer look.
RECENT HISTORY
Granada were promoted to Spain's top flight after a 35-year absence in 2011 but dropped out again in 2017 despite the best efforts of Tony Adams, who was parachuted in to save them with seven games to go and a squad of 18 different nationalities.