The Reds will take on Derby County, PSV Eindhoven and Paris Saint-Germain in the first phase of the competition in the winter.
Ricky Sbragia’s side are to face Derby away from home first, with the fixture due to be played on Thursday 20 December.
After Premier League 2 encounters away to Aston Villa and at home to Fulham, the young Reds will resume their International Cup campaign with back-to-back matches at Leigh Sports Village.
United welcome Dutch side PSV on Thursday 17 January 2019 and French outfit PSG on Friday 26 January.
All matches will kick off at 19:00 GMT and are subject to change.