Manchester United 3-1 Reading: Erik ten Hag's team spoiled Paul Ince's return to Old Trafford and advanced to the fifth round of the FA Cup.
Marcus Rashford looked to have opened the scoring in the first-half when his header narrowly crossed the line. But the would-be goal was ultimately ruled out as Wout Weghorst had been offside.
But Ten Hag's side would take the lead after the interval when Casmiro picked up on a through ball from Antony and slid the ball beyond Joe Lumley in the visitor's goal.