Ruben Amorim's side fell behind when Phil Foden headed in Jeremy Doku's cross in the 18th minute.
Although still well in with a shout at the interval, two second-half goals by Erling Haaland ensured familiar foes in this fixture inspired the Reds' undoing, and there was no consolation effort towards the end, even if a number of chances came and went for the visitors on a difficult day.
FIRST HALF - BEHIND AT THE BREAK
It seemed imperative for United to weather an early storm yet, with a matter of seconds on the clock, Haaland managed to get behind our defence to flash an effort across the face of Altay Bayindir's goal.