Christian Eriksen, Jonny Evans and Victor Lindelof are among those departing, as their contracts come to an end.
Denmark midfielder Eriksen scored on his 108th and final appearance for the club, with a penalty in our 2-0 final-day win over Aston Villa at Old Trafford last month.
Lindelof and Evans also featured in that game, bringing up their 284th and 241st appearances, respectively.
For Sweden captain Lindelof, it brought down the curtain on an eight-year United career that has seen him win Emirates FA Cup and League Cup winners’ medals, alongside Eriksen. Evans, meanwhile, leaves with an array of honours earned over his two spells at United, since making his debut as an Academy graduate in 2007.