The reigning Premier League Player of the Month has been in excellent form of late, since winning his place back in the side.
He had done well again, performing with confidence, but pulled up with what looked like an issue with his groin, in the 38th minute. As he held off Jamal Musiala, he winced in pain as play was halted.
After receiving treatment, Maguire tried to give it a go but was, almost instantly, forced to admit defeat and left the field, saluting the supporters who offered him a warm ovation.
The experienced Jonny Evans took his place at the heart of the back four, alongside the recalled Raphael Varane.